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Must understand water and its properties.
- Why? Macromolecular components (i.e. proteins) assume shapes in response to water.
- Most metabolic machinery operates in an aqueous environment.
Properties of Water
Covalent bonds (electron pair is shared) between oxygen and hydrogen atoms with a bond angle of 104.5o.
Oxygen atom is more electronegative that hydrogen atom --> electrons spend more time around oxygen atom than hydrogen atom --> result is a POLAR covalent bond.
Creates a permanent dipole in the molecule.
Can determine relative solubility of molecules “like dissolves like”.
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